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KMID : 0043320040270111093
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Archives of Pharmacal Research
2004 Volume.27 No. 11 p.1093 ~ p.1098
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Synthesis and Antimicrobial Activity of Certain Novel Quinoxalines
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Refaat Hanan-M.
Moneer Ashraf-A.
Khalil Omneya-M.
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Abstract
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In this study, certain 3-methyl-2-[4-(substituted amino carbonyl)anilino] quinoxalines, (2a-d) and (3a-d), were synthesized from the new key compound 2-[4-(ethoxycarbonyl)anilino]-3-methyl quinoxaline (1). In addition, a series of 2-[4-(arylidene hydrazinocarbonyl)anilino]-3-methyl quinoxalines (5a-e), as well as their cyclized oxadiazolinyl derivatives (6a-e), and a series of 2-[4--acylhydrazinocarbonyl)anilino]-3-methyl quinoxalines (7a-d), as well as their cyclized oxadiazolyl derivatives (8a-d) were also prepared. Some of these derivatives were evaluated for antimicrobial activity in vitro. It was found that all the selected compounds exhibit antimicrobial activity and that compound 5b had a broad spectrum of activity.
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KEYWORD
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2-[4-(Ethoxycarbonyl) anilino]-3-methylquinoxaline, Oxadiazolyl quinoxalires, Antimicrobial agents
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